Research Use Only: This product is supplied for laboratory research and in-vitro studies. Not for human or veterinary administration.
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Thymosin Alpha-1
- 28-Amino Acid Immunomodulator: N-terminal fragment of prothymosin alpha (Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN), originally isolated from thymus 1977, 3,000+ publications, thymalfasin (Zadaxin) approved in 35+ countries
- Pleiotropic Immune Activation: TLR2/3/4/7/9 agonist, dendritic cell activation, T-cell maturation (CD4+/CD8+), Th1 polarization (IL-2/IL-12/IFN-γ↑), NK cell enhancement, PD-1/Tim-3 exhaustion marker reduction
- Clinical Status: FDA orphan drug (DiGeorge anomaly, melanoma, hepatitis B, HCC), China approved for hepatitis B/HCC, COVID-19 mortality reduction (11.11% vs 30.00%, Liu et al. 2020), sepsis meta-analysis 41% mortality reduction
- Mechanistic pathway studies
- In vitro receptor profiling
- HPLC verified identity and purity
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Research Overview
Thymosin Alpha-1 (Tα1; also referenced as thymalfasin in portions of the literature) is a 28-amino-acid peptide originally characterized from thymic peptide fractions and widely used as a laboratory reagent in experimental immunology and cell signaling research. Published studies include in vitro cellular systems and in vivo animal models that evaluate Tα1-driven modulation of pattern-recognition receptor signaling, antigen-presenting cell maturation, cytokine network behavior, and downstream transcriptional programs.
Within research settings, Tα1 is commonly studied for its effects on innate/adaptive signaling crosstalk, dendritic cell functional state, T-cell polarization dynamics, and pathway-level biomarkers measured under controlled experimental conditions.
This product is intended exclusively for in vitro laboratory research by qualified professionals. Not for human consumption. Not approved by the FDA.
Published Research Briefs
Our research team has published evidence-checked briefs covering the science behind this compound. Each brief reviews primary sources and grades claims independently.