Research Use Only: This product is supplied for laboratory research and in-vitro studies. Not for human or veterinary administration.
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Identity Verified: LC-MS
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Reta (10mg)
- First-in-Class Triple Agonist: 39 aa peptide simultaneously activating GIPR (EC₅₀ 0.0643 nM), GLP-1R (EC₅₀ 0.775 nM), GCGR (EC₅₀ 5.79 nM), GIP backbone with Aib/C20 fatty diacid, t½ 6 days, once-weekly
- Superior Efficacy: Phase 2 obesity 24.2% weight loss at 48 weeks (12 mg), MASLD 82.4% liver fat reduction, T2D HbA1c -2.02%, 100+ publications, 100% ≥5% weight loss responders
- Clinical Development: Phase 3 TRIUMPH program (5,800+ participants), TRIUMPH-4 showed 26.4-28.7% weight loss at 68 weeks, TRANSCEND cardiovascular outcomes program, dose-dependent GI AEs
- Mechanistic pathway studies
- In vitro receptor profiling
- HPLC verified identity and purity
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Research Overview
Retatrutide (10mg) - Advanced Triple Receptor Agonist Research Compound Molecular Profile: Retatrutide is a 39-amino acid synthetic peptide with molecular weight ~4,600 Da (CAS 2381089-83-2). Features GIP peptide backbone conjugated to C20 fatty diacid moiety with Aib modifications for DPP-4 resistance and extended half-life. Triple Agonist Mechanism: Simultaneously activates three class B1 GPCRs - GIPR (EC₅₀: 0.0643 nM), GLP-1R (EC₅₀: 0.775 nM), and GCGR (EC₅₀: 5.79 nM). This "triple G" mechanism enables synergistic metabolic pathway investigation through combined incretin and glucagon receptor signaling. Thermogenesis & Energy Expenditure: GCGR agonism component increases metabolic rate, promotes mitochondrial biogenesis, activates brown adipose tissue, and enhances hepatic fatty acid oxidation - providing unique research applications for energy expenditure mechanisms. Product Specifications: - Purity: ≥95% by HPLC - Appearance: White to off-white lyophilized powder - Solubility: Soluble in water, PBS, physiological buffers - Storage: -20°C or -80°C long-term; 2-8°C short-term - Quality Control: Identity confirmed by MS, purity by HPLC, CoA available Laboratory Use Only Disclaimer: FOR RESEARCH USE ONLY. NOT FOR HUMAN OR VETERINARY USE. This research-grade compound is intended exclusively for laboratory investigations by qualified professionals. Not approved for clinical, diagnostic, or therapeutic applications. Handle with appropriate PPE in controlled laboratory environments. IACUC/IRB approval required for applicable studies. Purchaser assumes all liability for proper use and regulatory compliance.
This product is intended exclusively for in vitro laboratory research by qualified professionals. Not for human consumption. Not approved by the FDA.
Published Research Briefs
Our research team has published evidence-checked briefs covering the science behind this compound. Each brief reviews primary sources and grades claims independently.