MOTS-c (40mg)

MOTS-c (40mg) - Mitochondrial-Derived Peptide Research Compound Molecular Profile: MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a 16-amino acid mitochondrial-derived peptide with sequence Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR), molecular formula C₁₀₁H₁₅₂N₂₈O₂₂S₂, molecular weight 2,174.64 Da, and CAS 1627580-64-6. Discovered in 2015, MOTS-c is uniquely encoded by mitochondrial DNA within the 12S rRNA region, positioning it as a hormone-like messenger coordinating mitochondrial-nuclear communication. Mechanism of Action: MOTS-c activates AMPK through a unique mechanism involving folate-methionine cycle inhibition and accumulation of the metabolic intermediate AICAR (>20-fold elevation). This triggers phosphorylation of AMPKα at Thr172, promoting GLUT4 translocation, enhanced glucose uptake, fatty acid oxidation, and mitochondrial biogenesis. Under metabolic stress, MOTS-c translocates to the nucleus to directly regulate gene expression for cellular adaptation. Research Applications: This 40mg format provides extended research capacity for longitudinal metabolic studies, exercise mimetic research, aging biology investigations, and multi-model comparative studies. Product Specifications: - Purity: ≥98% (HPLC verified) - Form: Lyophilized powder - Content: 40 mg net peptide per vial - Storage: -20°C, protected from light and moisture - Certificate of Analysis provided Laboratory Use Only: This product is intended strictly for in-vitro research applications. NOT FOR HUMAN CONSUMPTION. Not approved by FDA or any regulatory agency for therapeutic use. Intended for qualified researchers and licensed laboratory facilities only.