SLU-PP-332 (250 mcg – 100 Capsules)

SLU-PP-332 (250 mcg – 100 Capsules) - Pan-ERR Agonist Exercise Mimetic Research Compound Molecular Profile: SLU-PP-332 (SR9861) is a pan-agonist of estrogen receptor-related receptors (ERRα/β/γ) with IUPAC name (E)-4-Hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide. Molecular formula C₁₈H₁₄N₂O₂, molecular weight 290.32 Da, CAS 303760-60-3. The compound demonstrates selectivity over estrogen receptors (ERα, ERβ) and other closely related nuclear receptors. Mechanism of Action: SLU-PP-332 activates all three ERR isoforms with highest potency for ERRα: EC₅₀ values of ERRα = 98 nM, ERRβ = 230 nM, ERRγ = 430 nM in cell-based cotransfection/reporter assays. As an "exercise mimetic," SLU-PP-332 increases mitochondrial function and cellular respiration in skeletal muscle cells. In mice, the compound increases fast oxidative skeletal muscle fibers (Type IIa) and enhances exercise endurance through ERRα-specific mechanisms. ERRs regulate genes involved in mitochondrial biogenesis, oxidative phosphorylation, and metabolic adaptation. Research Applications: This capsule format supports investigation of ERR nuclear receptor biology, exercise mimetic mechanisms, mitochondrial biogenesis, and metabolic adaptation pathways. Product Specifications: - Purity: ≥98% (HPLC verified) - Form: Oral capsules - Content: 250 mcg per capsule, 100 capsules (25 mg total) - Storage: Room temperature, protected from light - Certificate of Analysis provided Laboratory Use Only: This product is intended strictly for in-vitro research applications. NOT FOR HUMAN CONSUMPTION. Investigational compound. Intended for qualified researchers only.