PT-141 (10 mg)

PT-141 (Bremelanotide) Research Compound Molecular Profile: PT-141 is a synthetic cyclic heptapeptide with the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH. This compound features a homodetic cyclic structure stabilized by an Asp-Lys lactam bridge, N-terminal acetylation for enhanced enzymatic stability, and D-phenylalanine incorporation for resistance to proteolytic degradation. Molecular Formula: C₅₀H₆₈N₁₄O₁₀ Molecular Weight: ~1,025 Da CAS Number: 189691-06-3 Appearance: White to off-white lyophilized powder Purity: ≥98% (HPLC) Mechanism of Action: PT-141 functions as a non-selective melanocortin receptor agonist with preferential activity at MC3R and MC4R subtypes. The binding affinity hierarchy is MC1R > MC4R > MC3R > MC5R > MC2R. At therapeutically relevant concentrations, PT-141 demonstrates strongest functional activity at MC1R, MC4R, and MC3R, with MC4R showing particularly important CNS-mediated effects. The compound operates through central nervous system mechanisms, crossing the blood-brain barrier to engage melanocortin receptors in key hypothalamic nuclei including the paraventricular nucleus (PVN) and medial preoptic area (mPOA). These GPCRs couple primarily to Gαs proteins, stimulating adenylate cyclase activity and increasing cAMP production as the primary second messenger cascade. Research Applications: PT-141 serves as a valuable research tool for investigating melanocortin receptor pharmacology, CNS pathway modulation, and the integration of melanocortin and dopaminergic systems. Key research areas include receptor subtype characterization, hypothalamic circuit analysis, behavioral neuroscience, and comparative pharmacology studies of melanocortin peptides. Product Specifications: • Catalog/SKU: RP-PT-10MG • Quantity: 10 mg • Identity: Confirmed by mass spectrometry • Purity: Verified by HPLC • Peptide content: Determined by amino acid analysis • Certificate of Analysis (CoA): Available upon request Storage Conditions: • Store at -20°C in freezer, protected from light and moisture • Reconstituted solutions: Store at 4°C and use within 14 days, or aliquot and store at -20°C for extended storage • Avoid repeated freeze-thaw cycles Reconstitution: Reconstitute in sterile water, PBS, or appropriate buffer. Gently mix; do not vortex vigorously. Allow powder to fully dissolve before use. Laboratory Use Disclaimer: FOR RESEARCH USE ONLY. NOT FOR HUMAN OR VETERINARY USE. This product is intended solely for laboratory research purposes by qualified professionals. PT-141 (Bremelanotide) is provided as a research reagent for in vitro and in vivo experimental applications in controlled laboratory settings. Important Restrictions: • This product is NOT intended for human consumption, clinical use, or therapeutic application • This product is NOT intended for veterinary use or administration to animals outside approved research protocols • This product is NOT intended for use as a drug, food additive, or dietary supplement • Use must comply with all applicable local, state, and federal regulations Researcher Responsibilities: • Users must have appropriate training and qualifications for handling research peptides • All experiments must be conducted in accordance with institutional biosafety and ethics guidelines • Appropriate safety protocols must be followed, including use of personal protective equipment • Handle in accordance with good laboratory practices Safety Information: • Avoid inhalation, ingestion, and contact with skin and eyes • Use in well-ventilated area with appropriate safety equipment • Dispose of according to institutional and regulatory waste disposal protocols • In case of accidental exposure, seek medical attention Liability: The manufacturer and distributor assume no responsibility for improper handling, storage, or use of this product. Users assume all risk and liability associated with the use of this research material. This product is provided "as is" without any warranty, express or implied.