Ipamorelin (5 mg)

Ipamorelin (5 mg) - Research-Grade Growth Hormone Secretagogue Molecular Profile: Ipamorelin (NNC 26-0161) is a synthetic pentapeptide representing the first selective agonist of the ghrelin/growth hormone secretagogue receptor (GHS-R1a). Originally developed by Novo Nordisk, this compound exhibits a unique selectivity profile combining potent GH-releasing activity with GHRH-like hormonal specificity. Structure: Aib-His-D-2-Nal-D-Phe-Lys-NH₂ (pentapeptide) Molecular Formula: C₃₈H₄₉N₉O₅ Molecular Weight: 711.85 Da CAS Number: 170851-70-4 Purity: ≥98% (HPLC) Form: Lyophilized powder Mechanism of Action: Ipamorelin functions as a selective GHS-R1a agonist, triggering Gq/11-mediated signaling cascades involving phospholipase C activation, IP₃-dependent calcium mobilization, and PKC activation. The compound demonstrates equipotent GH release (EC₅₀ = 1.3 nmol/L) compared to GHRP-6, while uniquely exhibiting no stimulation of ACTH, cortisol, or prolactin—even at doses exceeding 200-fold higher than the effective dose for GH stimulation. This selectivity pattern distinguishes ipamorelin from other growth hormone secretagogues and closely resembles endogenous GHRH, despite acting through a different receptor pathway. Research Applications: The compound's well-characterized pharmacology and unique selectivity profile make it valuable for GHS-R1a receptor signaling studies, growth hormone axis research, selective secretagogue development, pituitary somatotroph function assessment, metabolic research independent of cortisol effects, and gastrointestinal motility investigations. The absence of ACTH/cortisol co-release enables precise investigation of GH-specific physiological effects without confounding HPA axis activation. Specifications: • Purity: ≥98% (HPLC verified) • Appearance: White to off-white lyophilized powder • Storage: -20°C (unopened), 2-8°C (reconstituted, use within 30 days) • Package Size: 5 mg per vial • Quality Control: HPLC purity determination, MS molecular weight confirmation, amino acid analysis, endotoxin testing (LAL assay) • Certificate of Analysis provided with each shipment Laboratory Use Only: FOR RESEARCH AND LABORATORY USE ONLY. This product is intended solely for research, analytical, and educational purposes. It is NOT approved for human consumption, medical use, clinical application, or any diagnostic or therapeutic purpose. Not a drug, food, cosmetic, or medical device. Not for human or veterinary administration. Researchers must comply with all applicable regulations. Purchaser assumes all responsibility for proper handling, storage, use, and disposal.