Glutathione (1500 mg)

Glutathione (1500 mg) - Research Grade Tripeptide Molecular Profile: Glutathione (GSH) is a tripeptide composed of glutamic acid, cysteine, and glycine with molecular formula C₁₀H₁₇N₃O₆S (307.32 g/mol, CAS 70-18-8). The molecule features a unique γ-glutamyl linkage between glutamate's gamma carboxyl group and cysteine's alpha amino group, conferring resistance to most peptidases. The cysteine residue contains a reactive sulfhydryl (-SH) group essential for redox chemistry, enabling participation in disulfide exchange reactions, nucleophilic conjugation, and electron donation to reduce oxidized species. Redox Cycling Mechanism: Glutathione exists in reduced (GSH) and oxidized (GSSG) forms that participate in cellular redox homeostasis. The reaction 2 GSH ⇌ GSSG + 2H⁺ + 2e⁻ is reversible via glutathione reductase (GSSG + NADPH + H⁺ → 2 GSH + NADP⁺). The GSH/GSSG ratio (typically >100:1 in healthy cells) serves as a critical biomarker for cellular redox status. Research Applications: • Glutathione Peroxidase (GPx) System Studies: Enzymatic defense against hydrogen peroxide and lipid peroxides via GSH-dependent reduction mechanisms • Glutathione S-Transferase (GST) Conjugation Research: Phase II detoxification pathway investigation involving nucleophilic attack by thiolate anion on electrophilic substrates • Phase II Detoxification Pathways: Mercapturic acid pathway studies, xenobiotic conjugation, and elimination of reactive metabolites • Redox Biology and Protein Glutathionylation: Investigation of reversible post-translational modifications regulating protein function under oxidative stress • Mitochondrial Redox Homeostasis: Studies of mGSH as primary mitochondrial antioxidant defense in catalase-absent organelles • Thiol Group Chemistry: Disulfide exchange reactions, mixed disulfide formation, and cysteine reservoir function Specifications: • Chemical Name: γ-L-Glutamyl-L-cysteinyl-glycine (Glu-Cys-Gly) • Molecular Formula: C₁₀H₁₇N₃O₆S • Molecular Weight: 307.32 g/mol • CAS Number: 70-18-8 • Purity: ≥98% (HPLC) • Appearance: White to off-white crystalline powder • Storage: -20°C, desiccated, protected from light and moisture Laboratory Use Only Disclaimer: This glutathione research compound is intended FOR LABORATORY RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION, administration, or therapeutic applications. This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease. For use only by qualified research personnel with appropriate training in laboratory safety procedures and chemical handling. Users are responsible for implementing appropriate safety measures, complying with all applicable regulations, and proper storage, handling, and disposal. Consult Safety Data Sheet (SDS) for comprehensive hazard and handling information.