Cagrilintide (10mg)

Cagrilintide (RP-CAGR-10MG) Research Peptide Molecular Profile: - Molecular Formula: C₁₉₄H₂₉₆N₅₄O₅₉S₂ (with C20 fatty acid modification) - Molecular Weight: ~4,400 Da - CAS Number: Not yet assigned (investigational compound) - Sequence Homology: 84% to native human amylin - Key Modifications: C20 fatty acid lipidation at Lys1, strategic amino acid substitutions (N14E, V17R, P25, P28, P29, P37Y) enabling extended half-life and preventing amyloid fibril formation - Half-Life: 159-195 hours (vs. minutes for native amylin) - Purity: ≥98% (HPLC) Research Applications: Cagrilintide is a dual amylin and calcitonin receptor agonist (DACRA) designed for investigating metabolic regulation mechanisms. The compound activates heterodimeric CALCR/RAMP receptor complexes (AMY1R, AMY2R, AMY3R) and enables research into: - CNS satiety circuit mapping via area postrema, nucleus tractus solitarius, and lateral parabrachial nucleus activation pathways - RAMP-mediated GPCR pharmacology investigating AMY1R (RAMP1) and AMY3R (RAMP3) weight-lowering mechanisms - Postprandial glucose regulation through gastric emptying modulation and glucagon suppression pathways - Synergistic metabolic pathway analysis in combination therapy models (amylin + GLP-1 receptor co-activation) - Structure-function relationship studies using cryo-EM validated peptide-receptor interaction determinants - Gut-brain axis communication mechanisms via vagal afferent signaling and circumventricular organ pathways Product Specifications: - Appearance: White to off-white lyophilized powder - Solubility: Soluble in water, PBS, or saline (pH 7.0-7.4) - Storage: -20°C, protected from light - Stability: 24 months when stored properly - Quality Control: Mass spectrometry identity confirmation, <1.0 EU/mg endotoxins - Certificate of Analysis: Provided with each batch Laboratory Use Only: This product is intended solely for in-vitro laboratory research by qualified researchers in appropriate research facilities. NOT approved for human consumption, medical use, clinical applications, or diagnostic purposes. Researchers must comply with all applicable regulations and maintain proper institutional oversight. By purchasing, buyer confirms understanding this product is sold strictly for laboratory research in controlled settings. Structural Data Reference: RCSB PDB 7BG0